The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system

Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD(50) of <0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD(50) of 10(4.2) PFU. To determine the basis for this difference in neurovirulence we have stu...

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Detalles Bibliográficos
Autores principales: Fazakerley, John K., Parker, Suezanne E., Bloom, Floyd, Buchmeier, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 1992
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131170/
https://www.ncbi.nlm.nih.gov/pubmed/1310555
http://dx.doi.org/10.1016/0042-6822(92)90306-A

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131170/
https://www.ncbi.nlm.nih.gov/pubmed/1310555
http://dx.doi.org/10.1016/0042-6822(92)90306-A

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