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The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system
Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD(50) of <0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD(50) of 10(4.2) PFU. To determine the basis for this difference in neurovirulence we have stu...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Published by Elsevier Inc.
1992
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131170/ https://www.ncbi.nlm.nih.gov/pubmed/1310555 http://dx.doi.org/10.1016/0042-6822(92)90306-A |