Computational design of closely related proteins that adopt two well-defined but structurally divergent folds

The plasticity of naturally occurring protein structures, which can change shape considerably in response to changes in environmental conditions, is critical to biological function. While computational methods have been used for de novo design of proteins that fold to a single state with a deep free...

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Detalles Bibliográficos
Autores principales: Wei, Kathy Y., Moschidi, Danai, Bick, Matthew J., Nerli, Santrupti, McShan, Andrew C., Carter, Lauren P., Huang, Po-Ssu, Fletcher, Daniel A., Sgourakis, Nikolaos G., Boyken, Scott E., Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132107/
https://www.ncbi.nlm.nih.gov/pubmed/32188784
http://dx.doi.org/10.1073/pnas.1914808117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132107/
https://www.ncbi.nlm.nih.gov/pubmed/32188784
http://dx.doi.org/10.1073/pnas.1914808117

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