Cargando…
Computational design of closely related proteins that adopt two well-defined but structurally divergent folds
The plasticity of naturally occurring protein structures, which can change shape considerably in response to changes in environmental conditions, is critical to biological function. While computational methods have been used for de novo design of proteins that fold to a single state with a deep free...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132107/ https://www.ncbi.nlm.nih.gov/pubmed/32188784 http://dx.doi.org/10.1073/pnas.1914808117 |