Proteasome mapping reveals sexual dimorphism in tissue‐specific sensitivity to protein aggregations

Defects in the proteasome can result in pathological proteinopathies. However, the pathogenic role of sex‐ and tissue‐specific sensitivity to proteotoxic stress remains elusive. Here, we map the proteasome activity across nine tissues, in male and female mice, and demonstrate strong sexual dimorphis...

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Detalles Bibliográficos
Autores principales: Jenkins, Edmund Charles, Shah, Nagma, Gomez, Maria, Casalena, Gabriella, Zhao, Dazhi, Kenny, Timothy C, Guariglia, Sara Rose, Manfredi, Giovanni, Germain, Doris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132179/
https://www.ncbi.nlm.nih.gov/pubmed/32090465
http://dx.doi.org/10.15252/embr.201948978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132179/
https://www.ncbi.nlm.nih.gov/pubmed/32090465
http://dx.doi.org/10.15252/embr.201948978

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