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Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch
Interleukin-2 (IL-2) is a small α-helical cytokine that regulates immune cell homeostasis through its recruitment to a high-affinity heterotrimeric receptor complex (IL-2Rα/IL-2Rβ/γ(c)). IL-2 has been shown to have therapeutic efficacy for immune diseases by preferentially expanding distinct T cell...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132253/ https://www.ncbi.nlm.nih.gov/pubmed/32184322 http://dx.doi.org/10.1073/pnas.2000419117 |