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Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread
Nef is an accessory protein of primate lentiviruses that is essential for efficient replication and pathogenesis of HIV-1. A conserved feature of Nef proteins from different lentiviral lineages is the ability to modulate host protein trafficking and down-regulate a number of cell surface receptors t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132320/ https://www.ncbi.nlm.nih.gov/pubmed/32179688 http://dx.doi.org/10.1073/pnas.1921135117 |