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Using protein engineering to understand and modulate aggregation

Protein aggregation occurs through a variety of mechanisms, initiated by the unfolded, non-native, or even the native state itself. Understanding the molecular mechanisms of protein aggregation is challenging, given the array of competing interactions that control solubility, stability, cooperativit...

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Detalles Bibliográficos
Autores principales: Ebo, Jessica S, Guthertz, Nicolas, Radford, Sheena E, Brockwell, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132541/
https://www.ncbi.nlm.nih.gov/pubmed/32087409
http://dx.doi.org/10.1016/j.sbi.2020.01.005