FX11 limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid through host-directed activity

Lactate dehydrogenase A (LDHA) mediates interconversion of pyruvate and lactate, and increased lactate turnover is exhibited by malignant and infected immune cells. Hypoxic lung granuloma in Mycobacterium tuberculosis-infected animals present elevated levels of Ldha and lactate. Such alterations in...

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Detalles Bibliográficos
Autores principales: Krishnamoorthy, Gopinath, Kaiser, Peggy, Abu Abed, Ulrike, Weiner, January, Moura-Alves, Pedro, Brinkmann, Volker, Kaufmann, Stefan H. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132771/
https://www.ncbi.nlm.nih.gov/pubmed/32034005
http://dx.doi.org/10.1242/dmm.041954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132771/
https://www.ncbi.nlm.nih.gov/pubmed/32034005
http://dx.doi.org/10.1242/dmm.041954

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