A simulation study comparing the power of nine tests of the treatment effect in randomized controlled trials with a time-to-event outcome

BACKGROUND: The logrank test is routinely applied to design and analyse randomized controlled trials (RCTs) with time-to-event outcomes. Sample size and power calculations assume the treatment effect follows proportional hazards (PH). If the PH assumption is false, power is reduced and interpretatio...

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Detalles Bibliográficos
Autores principales: Royston, Patrick, B. Parmar, Mahesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132898/
https://www.ncbi.nlm.nih.gov/pubmed/32252820
http://dx.doi.org/10.1186/s13063-020-4153-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132898/
https://www.ncbi.nlm.nih.gov/pubmed/32252820
http://dx.doi.org/10.1186/s13063-020-4153-2

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