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A simulation study comparing the power of nine tests of the treatment effect in randomized controlled trials with a time-to-event outcome
BACKGROUND: The logrank test is routinely applied to design and analyse randomized controlled trials (RCTs) with time-to-event outcomes. Sample size and power calculations assume the treatment effect follows proportional hazards (PH). If the PH assumption is false, power is reduced and interpretatio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132898/ https://www.ncbi.nlm.nih.gov/pubmed/32252820 http://dx.doi.org/10.1186/s13063-020-4153-2 |