A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers

In a double-blind placebo controlled trial intranasal NPC 567, a bradykinin antagonist, failed to alleviate the symptoms of experimental rhinovirus colds. Indeed, there was evidence that the drug enhanced the symptoms although no irritant effect was detected on the uninfected nasal mucosa.

Detalles Bibliográficos
Autores principales: Higgins, P.G., Barrow, G.I., Tyrrell, D.A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134172/
https://www.ncbi.nlm.nih.gov/pubmed/1965113
http://dx.doi.org/10.1016/0166-3542(90)90052-9
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author Higgins, P.G.
Barrow, G.I.
Tyrrell, D.A.J.
author_facet Higgins, P.G.
Barrow, G.I.
Tyrrell, D.A.J.
author_sort Higgins, P.G.
collection PubMed
description In a double-blind placebo controlled trial intranasal NPC 567, a bradykinin antagonist, failed to alleviate the symptoms of experimental rhinovirus colds. Indeed, there was evidence that the drug enhanced the symptoms although no irritant effect was detected on the uninfected nasal mucosa.
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spelling pubmed-71341722020-04-08 A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers Higgins, P.G. Barrow, G.I. Tyrrell, D.A.J. Antiviral Res Article In a double-blind placebo controlled trial intranasal NPC 567, a bradykinin antagonist, failed to alleviate the symptoms of experimental rhinovirus colds. Indeed, there was evidence that the drug enhanced the symptoms although no irritant effect was detected on the uninfected nasal mucosa. Published by Elsevier B.V. 1990-12 2002-11-12 /pmc/articles/PMC7134172/ /pubmed/1965113 http://dx.doi.org/10.1016/0166-3542(90)90052-9 Text en Copyright © 1990 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Higgins, P.G.
Barrow, G.I.
Tyrrell, D.A.J.
A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers
title A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers
title_full A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers
title_fullStr A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers
title_full_unstemmed A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers
title_short A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers
title_sort study of the efficacy of the bradykinin antagonist, npc 567, in rhinovirus infections in human volunteers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134172/
https://www.ncbi.nlm.nih.gov/pubmed/1965113
http://dx.doi.org/10.1016/0166-3542(90)90052-9
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