Inhibition of EGFR Signaling and Activation of Mitochondrial Apoptosis Contribute to Tanshinone IIA-Mediated Tumor Suppression in Non-Small Cell Lung Cancer Cells

BACKGROUND: Deregulation of epidermal growth factor receptor (EGFR) signaling plays a critical role in non-small cell lung cancer (NSCLC) tumorigenesis. The natural product Tanshinone IIA (Tan IIA) exhibits significant anti-tumor effect in various human cancers, however, the mechanism remains elusiv...

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Detalles Bibliográficos
Autores principales: Gao, Feng, Li, Ming, Liu, Wenbin, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135250/
https://www.ncbi.nlm.nih.gov/pubmed/32308411
http://dx.doi.org/10.2147/OTT.S246606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135250/
https://www.ncbi.nlm.nih.gov/pubmed/32308411
http://dx.doi.org/10.2147/OTT.S246606

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