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Selective imaging of solid tumours via the calcium-dependent high-affinity binding of a cyclic octapeptide to phosphorylated Annexin A2
The heterogeneity and continuous genetic adaptation of tumours complicate their detection and treatment via the targeting of genetic mutations. However, hallmarks of cancer such as aberrant protein phosphorylation and calcium-mediated cell signalling provide broadly conserved molecular targets. Here...
Autores principales: | Shen, Duanwen, Xu, Baogang, Liang, Kexian, Tang, Rui, Sudlow, Gail P., Egbulefu, Christopher, Guo, Kevin, Som, Avik, Gilson, Rebecca, Maji, Dolonchampa, Mondal, Suman, Habimana-Griffin, LeMoyne, Akers, Walter, Li, Shunqiang, Liu, Yang, Bloch, Sharon, Kurkure, Sid, Nussinov, Zohar, Seidel, Alexander, Tsen, Shaw-Wei D., Achilefu, Samuel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135742/ https://www.ncbi.nlm.nih.gov/pubmed/32165732 http://dx.doi.org/10.1038/s41551-020-0528-7 |
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