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Slit2 Protects Hearts Against Ischemia-Reperfusion Injury by Inhibiting Inflammatory Responses and Maintaining Myofilament Contractile Properties
BACKGROUND: The secreted glycoprotein Slit2, previously known as an axon guidance cue, has recently been found to protect tissues in pathological conditions; however, it is unknown whether Slit2 functions in cardiac ischemia–reperfusion (IR) injury. METHODS: Langendorff-perfused isolated hearts from...
Autores principales: | Li, Xiang, Zheng, Shuang, Tan, Weijiang, Chen, Hongqi, Li, Xiaohui, Wu, Jian, Luo, Ting, Ren, Xuecong, Pyle, W. Glen, Wang, Lijing, Backx, Peter H., Huang, Ren, Yang, Feng Hua |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135862/ https://www.ncbi.nlm.nih.gov/pubmed/32292352 http://dx.doi.org/10.3389/fphys.2020.00228 |
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