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Incomplete vesicular docking limits synaptic strength under high release probability conditions

Central mammalian synapses release synaptic vesicles in dedicated structures called docking/release sites. It has been assumed that when voltage-dependent calcium entry is sufficiently large, synaptic output attains a maximum value of one synaptic vesicle per action potential and per site. Here we u...

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Detalles Bibliográficos
Autores principales: Malagon, Gerardo, Miki, Takafumi, Tran, Van, Gomez, Laura C, Marty, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136020/
https://www.ncbi.nlm.nih.gov/pubmed/32228859
http://dx.doi.org/10.7554/eLife.52137