Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma

Brain metastases from lung adenocarcinoma (BM-LUAD) cause significant patient mortality. To identify genomic alterations that promote brain metastases, we performed whole-exome sequencing of 73 BM-LUAD cases. Using case-control analyses, we discovered candidate drivers of brain metastasis by identif...

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Detalles Bibliográficos
Autores principales: Shih, David J. H., Nayyar, Naema, Bihun, Ivanna, Dagogo-Jack, Ibiayi, Gill, Corey M., Aquilanti, Elisa, Bertalan, Mia, Kaplan, Alexander, D’Andrea, Megan R., Chukwueke, Ugonma, Ippen, Franziska Maria, Alvarez-Breckenridge, Christopher, Camarda, Nicholas D., Lastrapes, Matthew, McCabe, Devin, Kuter, Ben, Kaufman, Benjamin, Strickland, Matthew R., Martinez-Gutierrez, Juan Carlos, Nagabhushan, Deepika, De Sauvage, Magali, White, Michael D., Castro, Brandyn A., Hoang, Kaitlin, Kaneb, Andrew, Batchelor, Emily D., Paek, Sun Ha, Park, Sun Hye, Martinez-Lage, Maria, Berghoff, Anna S., Merrill, Parker, Gerstner, Elizabeth R., Batchelor, Tracy T., Frosch, Matthew P., Frazier, Ryan P., Borger, Darrell R., Iafrate, A. John, Johnson, Bruce E., Santagata, Sandro, Preusser, Matthias, Cahill, Daniel P., Carter, Scott L., Brastianos, Priscilla K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136154/
https://www.ncbi.nlm.nih.gov/pubmed/32203465
http://dx.doi.org/10.1038/s41588-020-0592-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136154/
https://www.ncbi.nlm.nih.gov/pubmed/32203465
http://dx.doi.org/10.1038/s41588-020-0592-7

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