Cargando…
mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway
T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy that is characterized by a high frequency of induction failure and by early relapse. Many studies have revealed that metadherin (MTDH) is highly expressed in a variety of malignant solid tumours and plays an impo...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136213/ https://www.ncbi.nlm.nih.gov/pubmed/32251289 http://dx.doi.org/10.1038/s41419-020-2380-9 |
_version_ | 1783518200809390080 |
---|---|
author | Li, Yiqing Chen, Jiaoting Yang, Wenjuan Liu, Hongyun Wang, Jieyu Xiao, Jie Xie, Shuangfeng Ma, Liping Nie, Danian |
author_facet | Li, Yiqing Chen, Jiaoting Yang, Wenjuan Liu, Hongyun Wang, Jieyu Xiao, Jie Xie, Shuangfeng Ma, Liping Nie, Danian |
author_sort | Li, Yiqing |
collection | PubMed |
description | T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy that is characterized by a high frequency of induction failure and by early relapse. Many studies have revealed that metadherin (MTDH) is highly expressed in a variety of malignant solid tumours and plays an important role in the occurrence and development of tumours. However, the relationship between the expression of MTDH and T-ALL has not yet been reported, and the regulatory factors of MTDH are still unknown. Our previous studies found that mPGES-1/PGE2 was important for promoting the growth of leukaemia cells. In the present study, we found that MTDH was highly expressed in primary T-ALL cells and in the Jurkat cell line. Our results showed that mPGES-1/PGE2 regulates the expression of MTDH through the EP3/cAMP/PKA-CREB pathway in T-ALL cells. Downregulation of MTDH inhibits the growth of Jurkat cells in vitro and in vivo. Our results suggest that MTDH could be a potential target for the treatment of T-ALL. |
format | Online Article Text |
id | pubmed-7136213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-71362132020-04-08 mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway Li, Yiqing Chen, Jiaoting Yang, Wenjuan Liu, Hongyun Wang, Jieyu Xiao, Jie Xie, Shuangfeng Ma, Liping Nie, Danian Cell Death Dis Article T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy that is characterized by a high frequency of induction failure and by early relapse. Many studies have revealed that metadherin (MTDH) is highly expressed in a variety of malignant solid tumours and plays an important role in the occurrence and development of tumours. However, the relationship between the expression of MTDH and T-ALL has not yet been reported, and the regulatory factors of MTDH are still unknown. Our previous studies found that mPGES-1/PGE2 was important for promoting the growth of leukaemia cells. In the present study, we found that MTDH was highly expressed in primary T-ALL cells and in the Jurkat cell line. Our results showed that mPGES-1/PGE2 regulates the expression of MTDH through the EP3/cAMP/PKA-CREB pathway in T-ALL cells. Downregulation of MTDH inhibits the growth of Jurkat cells in vitro and in vivo. Our results suggest that MTDH could be a potential target for the treatment of T-ALL. Nature Publishing Group UK 2020-04-06 /pmc/articles/PMC7136213/ /pubmed/32251289 http://dx.doi.org/10.1038/s41419-020-2380-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Li, Yiqing Chen, Jiaoting Yang, Wenjuan Liu, Hongyun Wang, Jieyu Xiao, Jie Xie, Shuangfeng Ma, Liping Nie, Danian mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway |
title | mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway |
title_full | mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway |
title_fullStr | mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway |
title_full_unstemmed | mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway |
title_short | mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway |
title_sort | mpges-1/pge2 promotes the growth of t-all cells in vitro and in vivo by regulating the expression of mtdh via the ep3/camp/pka/creb pathway |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136213/ https://www.ncbi.nlm.nih.gov/pubmed/32251289 http://dx.doi.org/10.1038/s41419-020-2380-9 |
work_keys_str_mv | AT liyiqing mpges1pge2promotesthegrowthoftallcellsinvitroandinvivobyregulatingtheexpressionofmtdhviatheep3camppkacrebpathway AT chenjiaoting mpges1pge2promotesthegrowthoftallcellsinvitroandinvivobyregulatingtheexpressionofmtdhviatheep3camppkacrebpathway AT yangwenjuan mpges1pge2promotesthegrowthoftallcellsinvitroandinvivobyregulatingtheexpressionofmtdhviatheep3camppkacrebpathway AT liuhongyun mpges1pge2promotesthegrowthoftallcellsinvitroandinvivobyregulatingtheexpressionofmtdhviatheep3camppkacrebpathway AT wangjieyu mpges1pge2promotesthegrowthoftallcellsinvitroandinvivobyregulatingtheexpressionofmtdhviatheep3camppkacrebpathway AT xiaojie mpges1pge2promotesthegrowthoftallcellsinvitroandinvivobyregulatingtheexpressionofmtdhviatheep3camppkacrebpathway AT xieshuangfeng mpges1pge2promotesthegrowthoftallcellsinvitroandinvivobyregulatingtheexpressionofmtdhviatheep3camppkacrebpathway AT maliping mpges1pge2promotesthegrowthoftallcellsinvitroandinvivobyregulatingtheexpressionofmtdhviatheep3camppkacrebpathway AT niedanian mpges1pge2promotesthegrowthoftallcellsinvitroandinvivobyregulatingtheexpressionofmtdhviatheep3camppkacrebpathway |