Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells

DNA damage results in mutations and plays critical roles in cancer development, progression, and treatment. Targeting DNA damage response in cancers by inhibiting poly-(ADP-ribose) polymerases (PARPs) offers an important therapeutic strategy. However, the failure of PARP inhibitors to markedly benef...

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Detalles Bibliográficos
Autores principales: Li, Songyu, Zhang, Yixiang, Wang, Na, Guo, Rong, Liu, Qiaoling, Lv, Changsheng, Wang, Jinguang, Wang, Lina, Yang, Qing-kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136254/
https://www.ncbi.nlm.nih.gov/pubmed/32249776
http://dx.doi.org/10.1038/s41419-020-2408-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136254/
https://www.ncbi.nlm.nih.gov/pubmed/32249776
http://dx.doi.org/10.1038/s41419-020-2408-1

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