FBXO22 degrades nuclear PTEN to promote tumorigenesis

Nuclear localization of PTEN is essential for its tumor suppressive role, and loss of nuclear PTEN is more prominent than cytoplasmic PTEN in many kinds of cancers. However, nuclear PTEN-specific regulatory mechanisms were rarely reported. Based on the finding that nuclear PTEN is more unstable than...

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Detalles Bibliográficos
Autores principales: Ge, Meng-Kai, Zhang, Na, Xia, Li, Zhang, Cheng, Dong, Shuang-Shu, Li, Zhan-Ming, Ji, Yan, Zheng, Min-Hua, Sun, Jing, Chen, Guo-Qiang, Shen, Shao-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136256/
https://www.ncbi.nlm.nih.gov/pubmed/32249768
http://dx.doi.org/10.1038/s41467-020-15578-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136256/
https://www.ncbi.nlm.nih.gov/pubmed/32249768
http://dx.doi.org/10.1038/s41467-020-15578-1

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