Antifibrotic Effects of a Barbituric Acid Derivative on Liver Fibrosis by Blocking the NF-κB Signaling Pathway in Hepatic Stellate Cells

Hepatic stellate cells (HSCs) are the major profibrogenic cells that promote the pathogenesis of liver fibrosis. The crosstalk between transforming growth factor-β1 (TGF-β1) signaling and lipopolysaccharide (LPS)-induced NF-κB signaling plays a critical role in accelerating liver fibrogenesis. Until...

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Detalles Bibliográficos
Autores principales: Wang, Yuan-Hsi, Suk, Fat-Moon, Liu, Chao-Lien, Chen, Tzu-Lang, Twu, Yuh-Ching, Hsu, Ming-Hua, Liao, Yi-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136425/
https://www.ncbi.nlm.nih.gov/pubmed/32296336
http://dx.doi.org/10.3389/fphar.2020.00388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136425/
https://www.ncbi.nlm.nih.gov/pubmed/32296336
http://dx.doi.org/10.3389/fphar.2020.00388

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