Cargando…

PI(3,4)P2 Signaling in Cancer and Metabolism

The phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) are central regulators of glycolysis, cancer metabolism, and cancer cell proliferation. At the molecular level, PI3K signaling involves the generation of the second messenger lipid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gozzelino, Luca, De Santis, Maria Chiara, Gulluni, Federico, Hirsch, Emilio, Martini, Miriam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136497/ https://www.ncbi.nlm.nih.gov/pubmed/32296634 http://dx.doi.org/10.3389/fonc.2020.00360

Ejemplares similares

Targeting PI3K in Cancer: Any Good News?
por: Martini, Miriam, et al.
Publicado: (2013)

Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer
por: Li, Huayi, et al.
Publicado: (2021)

PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney Cysts
por: De Santis, Maria Chiara, et al.
Publicado: (2017)

Signaling Pathways Regulating Redox Balance in Cancer Metabolism
por: De Santis, Maria Chiara, et al.
Publicado: (2018)

How PI3K-derived lipids control cell division
por: Campa, Carlo C., et al.
Publicado: (2015)

Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking
por: Margaria, Jean Piero, et al.
Publicado: (2019)

PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function
por: Franco, Irene, et al.
Publicado: (2014)

The role of metabolic adaptation to nutrient stress in pancreatic cancer
por: Derle, Abhishek, et al.
Publicado: (2018)

PTEN Regulates PI(3,4)P(2) Signaling Downstream of Class I PI3K
por: Malek, Mouhannad, et al.
Publicado: (2017)

PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress
por: Boukhalfa, Asma, et al.
Publicado: (2020)

Targeting PI3K/Akt/mTOR Signaling in Cancer
por: Porta, Camillo, et al.
Publicado: (2014)

The phospholipid PI(3,4)P(2) is an apical identity determinant
por: Román-Fernández, Álvaro, et al.
Publicado: (2018)

Structural basis of phosphatidylinositol 3-kinase C2α function
por: Lo, Wen-Ting, et al.
Publicado: (2022)

Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P(2)/PI(3,4)P(2)
por: Dong, Jiangqing, et al.
Publicado: (2019)

Targeting PI3K/mTOR Signaling in Cancer
por: Arcaro, Alexandre
Publicado: (2014)

Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth
por: Cisse, Ouma, et al.
Publicado: (2019)

METTL3 Is Suppressed by Circular RNA circMETTL3/miR-34c-3p Signaling and Limits the Tumor Growth and Metastasis in Triple Negative Breast Cancer
por: Ruan, Han-guang, et al.
Publicado: (2021)

LSD1 Activates PI3K/AKT Signaling Through Regulating p85 Expression in Prostate Cancer Cells
por: Wang, Zifeng, et al.
Publicado: (2019)

Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer
por: De Santis, Maria Chiara, et al.
Publicado: (2023)

PI3Kβ links integrin activation and PI(3,4)P(2) production during invadopodial maturation
por: Erami, Zahra, et al.
Publicado: (2019)

Loss of the Fbw7 tumor suppressor rewires cholesterol metabolism in cancer cells leading to activation of the PI3K-AKT signalling axis
por: Bengoechea-Alonso, Maria T., et al.
Publicado: (2022)

A high-avidity biosensor reveals plasma membrane PI(3,4)P(2) is predominantly a class I PI3K signaling product
por: Goulden, Brady D., et al.
Publicado: (2019)

YBX3 Mediates the Metastasis of Nasopharyngeal Carcinoma via PI3K/AKT Signaling
por: Fan, Xiaoqin, et al.
Publicado: (2021)

p110δ PI3 kinase pathway: emerging roles in cancer
por: Tzenaki, Niki, et al.
Publicado: (2013)

PI3K class II α: a novel regulator of vesicular trafficking at the base of the primary cilium
por: Franco, I, et al.
Publicado: (2012)

Targeting PI3K, FGFR, CDK4/6 Signaling Pathways Together With Cytostatics and Radiotherapy in Two Medulloblastoma Cell Lines
por: Lukoseviciute, Monika, et al.
Publicado: (2021)

INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway
por: Sun, Xiaoming, et al.
Publicado: (2022)

Heterozygous p53-R280T Mutation Enhances the Oncogenicity of NPC Cells Through Activating PI3K-Akt Signaling Pathway
por: Qin, Zhen-Qi, et al.
Publicado: (2020)

LRIG3 Suppresses Angiogenesis by Regulating the PI3K/AKT/VEGFA Signaling Pathway in Glioma
por: Peng, Chenghao, et al.
Publicado: (2021)

IL-1β Promotes Vasculogenic Mimicry of Breast Cancer Cells Through p38/MAPK and PI3K/Akt Signaling Pathways
por: Nisar, Muhammad Azhar, et al.
Publicado: (2021)

Study of iron metabolism based on T2* mapping sequences in PI-RADS 3 prostate lesions
por: D, Wenhao, et al.
Publicado: (2023)

Fibroblast-Induced Paradoxical PI3K Pathway Activation in PTEN-Competent Colorectal Cancer: Implications for Therapeutic PI3K/mTOR Inhibition
por: Conciatori, Fabiana, et al.
Publicado: (2022)

Mutually inhibitory Ras-PI(3,4)P(2) feedback loops mediate cell migration
por: Li, Xiaoguang, et al.
Publicado: (2018)

TIPE Regulates DcR3 Expression and Function by Activating the PI3K/AKT Signaling Pathway in CRC
por: Zhong, Mengya, et al.
Publicado: (2021)

Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions
por: Costa, Carlotta, et al.
Publicado: (2010)

Dissecting the PI3K Signaling Axis in Pediatric Solid Tumors: Novel Targets for Clinical Integration
por: Loh, Amos H. P., et al.
Publicado: (2013)

PI3K Pathway in NSCLC
por: Martinez-Martí, Alex, et al.
Publicado: (2012)

Phosphoinositide Conversion Inactivates R‐RAS and Drives Metastases in Breast Cancer
por: Li, Huayi, et al.
Publicado: (2022)

Knockdown of SNORA47 Inhibits the Tumorigenesis of NSCLC via Mediation of PI3K/Akt Signaling Pathway
por: Yu, Huiqing, et al.
Publicado: (2021)

Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway
por: Zhu, Xinbing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g7t0jn3f0o9ja0k0vavvvtm2s2