LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis

Liver fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) proteins and enzymes, especially fibrillary collagens, and represents a major cause of morbidity and mortality worldwide. Lysyl oxidases (LOXs) drive covalent crosslinking of collagen fibers, thereby promotin...

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Detalles Bibliográficos
Autores principales: Klepfish, Mordehay, Gross, Tamar, Vugman, Milena, Afratis, Nikolaos A., Havusha-Laufer, Sapir, Brazowski, Eli, Solomonov, Inna, Varol, Chen, Sagi, Irit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136575/
https://www.ncbi.nlm.nih.gov/pubmed/32296422
http://dx.doi.org/10.3389/fimmu.2020.00480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136575/
https://www.ncbi.nlm.nih.gov/pubmed/32296422
http://dx.doi.org/10.3389/fimmu.2020.00480

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