Egr1 Knockdown Combined with an ACE Inhibitor Ameliorates Diabetic Kidney Disease in Mice: Blockade of Compensatory Renin Increase

BACKGROUND: Increased compensatory intrarenal renin diminishes the efficacy of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in the treatment of diabetic kidney disease (DKD). Early growth response-1 (Egr1) is a crucial transcriptional factor in the progre...

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Detalles Bibliográficos
Autores principales: Hu, Fang, Xue, Rui, Wei, Xiaohong, Wang, Zheng, Luo, Shunkui, Lin, Jianghong, Yan, Zhixiang, Sun, Liao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136749/
https://www.ncbi.nlm.nih.gov/pubmed/32308450
http://dx.doi.org/10.2147/DMSO.S238138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136749/
https://www.ncbi.nlm.nih.gov/pubmed/32308450
http://dx.doi.org/10.2147/DMSO.S238138

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