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Egr1 Knockdown Combined with an ACE Inhibitor Ameliorates Diabetic Kidney Disease in Mice: Blockade of Compensatory Renin Increase

BACKGROUND: Increased compensatory intrarenal renin diminishes the efficacy of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in the treatment of diabetic kidney disease (DKD). Early growth response-1 (Egr1) is a crucial transcriptional factor in the progre...

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Detalles Bibliográficos
Autores principales:	Hu, Fang, Xue, Rui, Wei, Xiaohong, Wang, Zheng, Luo, Shunkui, Lin, Jianghong, Yan, Zhixiang, Sun, Liao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136749/ https://www.ncbi.nlm.nih.gov/pubmed/32308450 http://dx.doi.org/10.2147/DMSO.S238138

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