Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke

Cytosolic double‐stranded DNA (dsDNA) is a danger signal that is tightly monitored and sensed by nucleic acid‐sensing pattern recognition receptors. We study the inflammatory cascade on dsDNA recognition and investigate the neuroprotective effect of cyclic GMP‐AMP (cGAMP) synthase (cGAS) antagonist...

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Detalles Bibliográficos
Autores principales: Li, Qian, Cao, Yuze, Dang, Chun, Han, Bin, Han, Ranran, Ma, Heping, Hao, Junwei, Wang, Lihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136961/
https://www.ncbi.nlm.nih.gov/pubmed/32239625
http://dx.doi.org/10.15252/emmm.201911002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136961/
https://www.ncbi.nlm.nih.gov/pubmed/32239625
http://dx.doi.org/10.15252/emmm.201911002

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