Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies

BACKGROUND: The present study aimed to develop and validate a rapid, selective, and reproducible ultra-performance liquid chromatography-tandem mass spectrometry separation method for the simultaneous determination of the levels of parecoxib and its main metabolite valdecoxib in rat plasma. Moreover...

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Detalles Bibliográficos
Autores principales: Chen, Mengchun, Sun, Wei, Wang, Zhe, Huang, Chengke, Hu, Guoxin, Chen, Yijie, Wang, Ledan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137270/
https://www.ncbi.nlm.nih.gov/pubmed/32264977
http://dx.doi.org/10.1186/s40360-020-00406-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137270/
https://www.ncbi.nlm.nih.gov/pubmed/32264977
http://dx.doi.org/10.1186/s40360-020-00406-5

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