Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11

Ferroptosis is a type of adaptive cell death driven by cellular metabolism and iron‐dependent lipid peroxidation. Though multiple genes (including SLC7A11 and GPX4) have been demonstrated to play key roles in ferroptosis, little is known about the epigenetic regulation of this process. Here, we repo...

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Detalles Bibliográficos
Autores principales: Wang, Yishu, Zhao, Yao, Wang, Haihua, Zhang, Chengliang, Wang, Meiqi, Yang, Yong, Xu, Xin, Hu, Zhenbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137800/
https://www.ncbi.nlm.nih.gov/pubmed/32107878
http://dx.doi.org/10.1002/2211-5463.12823
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author Wang, Yishu
Zhao, Yao
Wang, Haihua
Zhang, Chengliang
Wang, Meiqi
Yang, Yong
Xu, Xin
Hu, Zhenbo
author_facet Wang, Yishu
Zhao, Yao
Wang, Haihua
Zhang, Chengliang
Wang, Meiqi
Yang, Yong
Xu, Xin
Hu, Zhenbo
author_sort Wang, Yishu
collection PubMed
description Ferroptosis is a type of adaptive cell death driven by cellular metabolism and iron‐dependent lipid peroxidation. Though multiple genes (including SLC7A11 and GPX4) have been demonstrated to play key roles in ferroptosis, little is known about the epigenetic regulation of this process. Here, we report that KDM3B, a histone H3 lysine 9 demethylase, can protect against ferroptosis induced by Erastin, an inhibitor of SLC7A11. KDM3B overexpression in HT‐1080 cells results in decreased histone H3 lysine 9 methylation. Furthermore, KDM3B upregulates the expression of SLC7A11 through cooperation with the transcription factor ATF4. In summary, we identify here KDM3B as a potential epigenetic regulator of ferroptosis.
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spelling pubmed-71378002020-04-08 Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11 Wang, Yishu Zhao, Yao Wang, Haihua Zhang, Chengliang Wang, Meiqi Yang, Yong Xu, Xin Hu, Zhenbo FEBS Open Bio Research Articles Ferroptosis is a type of adaptive cell death driven by cellular metabolism and iron‐dependent lipid peroxidation. Though multiple genes (including SLC7A11 and GPX4) have been demonstrated to play key roles in ferroptosis, little is known about the epigenetic regulation of this process. Here, we report that KDM3B, a histone H3 lysine 9 demethylase, can protect against ferroptosis induced by Erastin, an inhibitor of SLC7A11. KDM3B overexpression in HT‐1080 cells results in decreased histone H3 lysine 9 methylation. Furthermore, KDM3B upregulates the expression of SLC7A11 through cooperation with the transcription factor ATF4. In summary, we identify here KDM3B as a potential epigenetic regulator of ferroptosis. John Wiley and Sons Inc. 2020-03-18 /pmc/articles/PMC7137800/ /pubmed/32107878 http://dx.doi.org/10.1002/2211-5463.12823 Text en © 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Wang, Yishu
Zhao, Yao
Wang, Haihua
Zhang, Chengliang
Wang, Meiqi
Yang, Yong
Xu, Xin
Hu, Zhenbo
Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11
title Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11
title_full Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11
title_fullStr Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11
title_full_unstemmed Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11
title_short Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11
title_sort histone demethylase kdm3b protects against ferroptosis by upregulating slc7a11
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137800/
https://www.ncbi.nlm.nih.gov/pubmed/32107878
http://dx.doi.org/10.1002/2211-5463.12823
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