Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

BACKGROUND: We previously showed that small interfering RNAs (siRNAs) targeting the Zaire Ebola virus (ZEBOV) RNA polymerase L protein formulated in stable nucleic acid-lipid particles (SNALPs) completely protected guineapigs when administered shortly after a lethal ZEBOV challenge. Although rodent...

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Detalles Bibliográficos
Autores principales: Geisbert, Thomas W, Lee, Amy CH, Robbins, Marjorie, Geisbert, Joan B, Honko, Anna N, Sood, Vandana, Johnson, Joshua C, de Jong, Susan, Tavakoli, Iran, Judge, Adam, Hensley, Lisa E, MacLachlan, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138079/
https://www.ncbi.nlm.nih.gov/pubmed/20511019
http://dx.doi.org/10.1016/S0140-6736(10)60357-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138079/
https://www.ncbi.nlm.nih.gov/pubmed/20511019
http://dx.doi.org/10.1016/S0140-6736(10)60357-1

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