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The signal peptide as a new target for drug design

Many current and potential drug targets are membrane-bound or secreted proteins that are expressed and transported via the Sec61 secretory pathway. They are targeted to translocon channels across the membrane of the endoplasmic reticulum (ER) by signal peptides (SPs), which are temporary structures...

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Detalles Bibliográficos
Autores principales: Lumangtad, Liezel A., Bell, Thomas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138182/
https://www.ncbi.nlm.nih.gov/pubmed/32209293
http://dx.doi.org/10.1016/j.bmcl.2020.127115