Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites

Hyperphosphorylated tau protein is a pathological hallmark of numerous neurodegenerative diseases and the level of tau pathology is correlated with the degree of cognitive impairment. Tau hyper-phosphorylation is thought to be an early initiating event in the cascade leading to tau toxicity and neur...

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Detalles Bibliográficos
Autores principales: Dillon, Gregory M., Henderson, Jaclyn L., Bao, Channa, Joyce, John A., Calhoun, Michael, Amaral, Brenda, King, Kristopher W., Bajrami, Bekim, Rabah, Dania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138307/
https://www.ncbi.nlm.nih.gov/pubmed/32255788
http://dx.doi.org/10.1371/journal.pone.0228771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138307/
https://www.ncbi.nlm.nih.gov/pubmed/32255788
http://dx.doi.org/10.1371/journal.pone.0228771

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