Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation

In Parkinson’s disease, some of the first alpha-synuclein aggregates appear in the olfactory system and the dorsal motor nucleus of the vagus nerve before spreading to connected brain regions. We previously demonstrated that injection of alpha-synuclein fibrils unilaterally into the olfactory bulb o...

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Detalles Bibliográficos
Autores principales: Mezias, Christopher, Rey, Nolwen, Brundin, Patrik, Raj, Ashish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138530/
https://www.ncbi.nlm.nih.gov/pubmed/31628991
http://dx.doi.org/10.1016/j.nbd.2019.104623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138530/
https://www.ncbi.nlm.nih.gov/pubmed/31628991
http://dx.doi.org/10.1016/j.nbd.2019.104623

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