The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes

SOX2 is a core pluripotency-associated transcription factor causally related to cancer initiation, aggressiveness, and drug resistance by driving the self-renewal and seeding capacity of cancer stem cells (CSC). Here, we tested the ability of the clinically proven inhibitor of the lysine-specific de...

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Detalles Bibliográficos
Autores principales: Cuyàs, Elisabet, Gumuzio, Juan, Verdura, Sara, Brunet, Joan, Bosch-Barrera, Joaquim, Martin-Castillo, Begoña, Alarcón, Tomás, Encinar, José Antonio, Martin, Ángel G., Menendez, Javier A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138538/
https://www.ncbi.nlm.nih.gov/pubmed/32191225
http://dx.doi.org/10.18632/aging.102887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138538/
https://www.ncbi.nlm.nih.gov/pubmed/32191225
http://dx.doi.org/10.18632/aging.102887

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