HDAC6 promotes sepsis development by impairing PHB1-mediated mitochondrial respiratory chain function

Objective: This study was aimed at investigating the regulation of mitochondrial function by histone deacetylase 6 (HDAC6) and the role of HDAC6 in the development and progression of sepsis. Results: HDAC6 downregulated PHB1 and subsequently promoted the development of CLP-induced sepsis. Inhibition...

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Detalles Bibliográficos
Autores principales: Guo, Shi-dong, Yan, Sheng-tao, Li, Wen, Zhou, Hong, Yang, Jian-ping, Yao, Yao, Shen, Mei-jia, Zhang, Liu-wei, Zhang, Hong-Bo, Sun, Li-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138540/
https://www.ncbi.nlm.nih.gov/pubmed/32221047
http://dx.doi.org/10.18632/aging.102964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138540/
https://www.ncbi.nlm.nih.gov/pubmed/32221047
http://dx.doi.org/10.18632/aging.102964

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