Selective degradation of IKKα by autophagy is essential for arsenite-induced cancer cell apoptosis

Two catalytic subunits of the IKK complex, IKKα and IKKβ, trigger NF-κB activation as well as NF-κB-independent signaling events under both physiological and pathological conditions. Here we identified the NF-κB-unrelated cytoprotective function of IKKα in promoting autophagy by triggering p53 trans...

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Detalles Bibliográficos
Autores principales: Tan, Qixing, Zou, Shuxian, Jin, Rui, Hu, Yongliang, Xu, Huan, Wang, Hongli, Ding, Mengnan, Hu, Meiru, Wei, Changyuan, Song, Lun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138825/
https://www.ncbi.nlm.nih.gov/pubmed/32265434
http://dx.doi.org/10.1038/s41419-020-2420-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138825/
https://www.ncbi.nlm.nih.gov/pubmed/32265434
http://dx.doi.org/10.1038/s41419-020-2420-5

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