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TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits

The TrkB receptor is critical for the control of energy balance, as mutations in its gene (NTRK2) lead to hyperphagia and severe obesity. The main neural substrate mediating the appetite-suppressing activity of TrkB, however, remains unknown. Here, we demonstrate that selective Ntrk2 deletion within...

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Detalles Bibliográficos
Autores principales: An, Juan Ji, Kinney, Clint E., Tan, Ji-Wei, Liao, Guey-Ying, Kremer, Eric J., Xu, Baoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138837/
https://www.ncbi.nlm.nih.gov/pubmed/32265438
http://dx.doi.org/10.1038/s41467-020-15537-w