Astrocytes with TDP-43 inclusions exhibit reduced noradrenergic cAMP and Ca(2+) signaling and dysregulated cell metabolism

Most cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have cytoplasmic inclusions of TAR DNA-binding protein 43 (TDP-43) in neurons and non-neuronal cells, including astrocytes, which metabolically support neurons with nutrients. Neuronal metabolism largely depends on t...

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Detalles Bibliográficos
Autores principales: Velebit, Jelena, Horvat, Anemari, Smolič, Tina, Prpar Mihevc, Sonja, Rogelj, Boris, Zorec, Robert, Vardjan, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138839/
https://www.ncbi.nlm.nih.gov/pubmed/32265469
http://dx.doi.org/10.1038/s41598-020-62864-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138839/
https://www.ncbi.nlm.nih.gov/pubmed/32265469
http://dx.doi.org/10.1038/s41598-020-62864-5

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