Pooled Screens Identify GPR108 and TM9SF2 as Host Cell Factors Critical for AAV Transduction

Adeno-associated virus (AAV) has been used extensively as a vector for gene therapy. Despite its widespread use, the mechanisms by which AAV enters the cell and is trafficked to the nucleus are poorly understood. In this study, we performed two pooled, genome-wide screens to identify positive and ne...

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Detalles Bibliográficos
Autores principales: Meisen, W. Hans, Nejad, Zahra Bahrami, Hardy, Miki, Zhao, Huiren, Oliverio, Oliver, Wang, Songli, Hale, Christopher, Ollmann, Michael M., Collins, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139131/
https://www.ncbi.nlm.nih.gov/pubmed/32280726
http://dx.doi.org/10.1016/j.omtm.2020.03.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139131/
https://www.ncbi.nlm.nih.gov/pubmed/32280726
http://dx.doi.org/10.1016/j.omtm.2020.03.012

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