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Pooled Screens Identify GPR108 and TM9SF2 as Host Cell Factors Critical for AAV Transduction
Adeno-associated virus (AAV) has been used extensively as a vector for gene therapy. Despite its widespread use, the mechanisms by which AAV enters the cell and is trafficked to the nucleus are poorly understood. In this study, we performed two pooled, genome-wide screens to identify positive and ne...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139131/ https://www.ncbi.nlm.nih.gov/pubmed/32280726 http://dx.doi.org/10.1016/j.omtm.2020.03.012 |