Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth

In this study, the CAR-like multivalent aptamer nanoparticles (X-polymers) were assembled with the dimer of murine CD28 RNA aptamer (CD28Apt7), the tetramer of CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) RNA aptamer (Del60), and a folic acid labeled ssDNA fragment in a stable nucleic acid t...

Descripción completa

Detalles Bibliográficos
Autores principales: Bai, Chenjun, Gao, Shanshan, Hu, Sai, Liu, Xuemei, Li, Hui, Dong, Jie, Huang, Aixue, Zhu, Lingling, Zhou, Pingkun, Li, Shaohua, Shao, Ningsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139145/
https://www.ncbi.nlm.nih.gov/pubmed/32280743
http://dx.doi.org/10.1016/j.omto.2020.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139145/
https://www.ncbi.nlm.nih.gov/pubmed/32280743
http://dx.doi.org/10.1016/j.omto.2020.03.002

Ejemplares similares