Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy

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Kinesin-5 motors are vital mitotic spindle components, and disruption of their function perturbs cell division. We investigated the molecular mechanism of the human kinesin-5 inhibitor GSK-1, which allosterically promotes tight microtubule binding. GSK-1 inhibits monomeric human kinesin-5 ATPase and...

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Detalles Bibliográficos
Autores principales: Peña, Alejandro, Sweeney, Aaron, Cook, Alexander D., Topf, Maya, Moores, Carolyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139217/
https://www.ncbi.nlm.nih.gov/pubmed/32084356
http://dx.doi.org/10.1016/j.str.2020.01.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139217/
https://www.ncbi.nlm.nih.gov/pubmed/32084356
http://dx.doi.org/10.1016/j.str.2020.01.013

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