Computational Study on the Effect of Inactivating/Activating Mutations on the Inhibition of MEK1 by Trametinib

Activation of the mitogen-activated protein kinase (MAPK) signaling pathway regulated by human MAP kinase 1 (MEK1) is associated with the carcinogenesis and progression of numerous cancers. In addition, two active mutations (P124S and E203K) have been reported to enhance the activity of MEK1, thereb...

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Detalles Bibliográficos
Autores principales: Zhu, Jingxuan, Li, Congcong, Yang, Hengzheng, Guo, Xiaoqing, Huang, Tianci, Han, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139317/
https://www.ncbi.nlm.nih.gov/pubmed/32245216
http://dx.doi.org/10.3390/ijms21062167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139317/
https://www.ncbi.nlm.nih.gov/pubmed/32245216
http://dx.doi.org/10.3390/ijms21062167

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