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Computational Study on the Effect of Inactivating/Activating Mutations on the Inhibition of MEK1 by Trametinib

Activation of the mitogen-activated protein kinase (MAPK) signaling pathway regulated by human MAP kinase 1 (MEK1) is associated with the carcinogenesis and progression of numerous cancers. In addition, two active mutations (P124S and E203K) have been reported to enhance the activity of MEK1, thereb...

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Detalles Bibliográficos
Autores principales:	Zhu, Jingxuan, Li, Congcong, Yang, Hengzheng, Guo, Xiaoqing, Huang, Tianci, Han, Weiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139317/ https://www.ncbi.nlm.nih.gov/pubmed/32245216 http://dx.doi.org/10.3390/ijms21062167

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