Cargando…

High Prevalence of Alterations in DNA Mismatch Repair Genes of Lynch Syndrome in Pediatric Patients with Adrenocortical Tumors Carrying a Germline Mutation on TP53

Adrenocortical cancer is a rare malignant neoplasm associated with a dismal prognosis. Identification of the molecular pathways involved in adrenal tumorigenesis is essential for a better understanding of the disease mechanism and improvement of its treatment. The aim of this study is to define the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brondani, Vania Balderrama, Montenegro, Luciana, Lacombe, Amanda Meneses Ferreira, Magalhães, Breno Marchiori, Nishi, Mirian Yumie, Funari, Mariana Ferreira de Assis, Narcizo, Amanda de Moraes, Cardoso, Lais Cavalca, Siqueira, Sheila Aparecida Coelho, Zerbini, Maria Claudia Nogueira, Denes, Francisco Tibor, Latronico, Ana Claudia, Mendonca, Berenice Bilharinho, Almeida, Madson Queiroz, Lerario, Antonio Marcondes, Soares, Ibere Cauduro, Fragoso, Maria Candida Barisson Villares
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139318/ https://www.ncbi.nlm.nih.gov/pubmed/32156018 http://dx.doi.org/10.3390/cancers12030621

Ejemplares similares

SAT-155 High Prevalence Alterations on DNA Mismatch Repair Genes Related to Lynch Syndrome in Pediatric Patients with Adrenocortical Tumor Carried of the Germline Mutation on TP53
por: Brondani, Vânia Balderrama, et al.
Publicado: (2020)

Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma
por: Brondani, Vania Balderrama, et al.
Publicado: (2021)

SAT-165 Sterol O-Acyl Transferase 1 as a Prognostic Marker of Adrenocortical Carcinoma
por: Lacombe, Amanda Meneses Ferreira, et al.
Publicado: (2020)

Sterol O-Acyl Transferase 1 as a Prognostic Marker of Adrenocortical Carcinoma
por: Lacombe, Amanda Meneses Ferreira, et al.
Publicado: (2020)

SUN-180 A Case of Deoxycorticosterone-Producing Malignant Adrenocortical Tumor
por: Cartolano, Natasha Scaranello, et al.
Publicado: (2020)

SUN-218 Analysis of ATRX and ZNRF3 Expression and Copy Number Variation in a Pediatric and Adult Cohort with Adrenocortical Tumors
por: Brondani, Vânia Balderrama, et al.
Publicado: (2020)

SAT-178 Incidence, Patterns of Clinical Presentation, and Outcomes of Patients with Brain Metastasis Due to Adrenocortical Carcinoma
por: Amorim, Larissa Costa, et al.
Publicado: (2020)

Long-term Results after CT-Guided Percutaneous Ethanol Ablation for the Treatment of Hyperfunctioning Adrenal Disorders
por: Frenk, Nathan Elie, et al.
Publicado: (2016)

FRI256 The Clinical Impacts Of Bi-allelic Germline Pathogenic Variant In TP53 In Two Patients With Li-Fraumeni Syndrome
por: Petry, Vanessa, et al.
Publicado: (2023)

A New Insight into the Surgical Treatment of Primary Macronodular Adrenal Hyperplasia
por: Yoshiaki Tanno, Fabio, et al.
Publicado: (2020)

Amplification of the Insulin-Like Growth Factor 1 Receptor Gene Is a Rare Event in Adrenocortical Adenocarcinomas: Searching for Potential Mechanisms of Overexpression
por: Ribeiro, Tamaya Castro, et al.
Publicado: (2014)

SAT-LB34 Repressive Epigenetic Programs Reinforce Steroidogenic Differentiation and Wnt/β-Catenin Signaling in Aggressive Adrenocortical Carcinoma
por: Mohan, Dipika R, et al.
Publicado: (2020)

FRI188 Exploratory Genomic Analysis From A Brazilian PMAH-Family With ARMC5 Alteration With Insidious Pattern Progression Of The Disease
por: Charchar, Helaine Laiz, et al.
Publicado: (2023)

Retrospective Analysis of Prognostic Factors in Pediatric Patients with Adrenocortical Tumor from Unique Tertiary Center with Long-Term Follow-Up
por: Bachega, Fernanda S., et al.
Publicado: (2022)

POD-1/TCF21 Reduces SHP Expression, Affecting LRH-1 Regulation and Cell Cycle Balance in Adrenocortical and Hepatocarcinoma Tumor Cells
por: França, Monica Malheiros, et al.
Publicado: (2015)

FRI267 Carney Complex From A Single Familycarney Complex From A Single Family Followed Up Over 20 Years With Different Clinical Pattern Evolution
por: Kuhn, Aliny W, et al.
Publicado: (2023)

Allelic Variants of ARMC5 in Patients With Adrenal Incidentalomas and in Patients With Cushing's Syndrome Associated With Bilateral Adrenal Nodules
por: Mariani, Beatriz Marinho de Paula, et al.
Publicado: (2020)

FRI193 Early Presentation Of Pediatric Oncocytic Adrenal Tumor Associated With Germline TP53 Pathogenic Variant—Report Of Three Cases
por: Oppenheimer, Romulo R V, et al.
Publicado: (2023)

SUN-178 Clinical and Anatomopathological Characteristics of Two Atypical Aldosterone-Producing Adenomas
por: Goldbaum, Tatiana Silva, et al.
Publicado: (2020)

ODP144 Cushing Syndrome and Primary Hyperaldosteronism due to Synchronic Bilateral Adrenal Adenomas with Exclusive Production of Cortisol on the Right and Aldosterone on the Left
por: Rolim, Marina Rocha, et al.
Publicado: (2022)

MON-206 Diagnosis of Non-Functional Masses in Adrenal Gland Topography - Experience of a Tertiary Health Center
por: Brondani, Vânia Balderrama, et al.
Publicado: (2020)

SUN-172 A False Positive Result in Newborn Screening for Congenital Adrenal Hyperplasia (CAH) in a Girl with Beckwith Wiedemann Syndrome
por: Braga, Barbara Leitao, et al.
Publicado: (2020)

Glucose-dependent insulinotropic peptide receptor overexpression in adrenocortical hyperplasia in MEN1 syndrome without loss of heterozygosity at the 11q13 locus
por: Costa, Marcia Helena Soares, et al.
Publicado: (2011)

SUN-710 Custom Panel to Diagnosis Genetic Endocrine Disorders in a Tertiary Academic Hospital
por: Cardoso, Lais Cavalca, et al.
Publicado: (2020)

SUN-351 Are We Underestimating The Role Of Systemic Chemotherapy In The Treatment Of Localized And Advanced Adrenocortical Carcinoma?
por: Ferreira, Amanda, et al.
Publicado: (2019)

An Overview of the Heterogeneous Causes of Cushing Syndrome Resulting From Primary Macronodular Adrenal Hyperplasia (PMAH)
por: Charchar, Helaine Laiz Silva, et al.
Publicado: (2022)

Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma
por: de Sousa, Gabriela Resende Vieira, et al.
Publicado: (2015)

Corrigendum: Transcriptome Analysis Showed a Differential Signature Between Invasive and Non-invasive Corticotrophinomas
por: de Araújo, Leonardo Jose Tadeu, et al.
Publicado: (2019)

Transcriptome Analysis Showed a Differential Signature between Invasive and Non-invasive Corticotrophinomas
por: de Araújo, Leonardo Jose Tadeu, et al.
Publicado: (2017)

SUN-382 Heterogeneous Clinical Presentation In Familial Cases Of Primary Macronodular Adrenal Hyperplasia (PMAH): The Influence Of Somatic Event Of ARMC5.
por: Brondani, Vânia, et al.
Publicado: (2019)

Genotype analysis of the human endostatin variant p.D104N in benign and malignant adrenocortical tumors
por: de Paula Mariani, Beatriz Marinho, et al.
Publicado: (2012)

SELAdb: A database of exonic variants in a Brazilian population referred to a quaternary medical center in São Paulo
por: Lerario, Antonio Marcondes, et al.
Publicado: (2020)

ARMC5 mutations are associated with high levels of proliferating cell nuclear antigen and the presence of the serotonin receptor 5HT4R in PMAH nodules
por: da Conceição, Barbara Brito, et al.
Publicado: (2020)

Resolution of Cyclicity After Pasireotide LAR in a Patient With Cushing Disease
por: Machado, Márcio Carlos, et al.
Publicado: (2021)

THU587 High Prevalence Of Primary Aldosteronism Diagnosis In Patients With Papillary Thyroid Cancer And Hypertension: A Cross-sectional Case-control Study
por: Ana Wolf, Ana Alice Wolf Maciel, et al.
Publicado: (2023)

OR29-3 Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma
por: Mohan, Dipika, et al.
Publicado: (2019)

TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical Tumors
por: Passaia, Barbara dos Santos, et al.
Publicado: (2018)

The Role of gsp Mutations on the Development of Adrenocortical Tumors and Adrenal Hyperplasia
por: Villares Fragoso, Maria Candida Barisson, et al.
Publicado: (2016)

Primary malignant tumors of the adrenal glands
por: Almeida, Madson Q, et al.
Publicado: (2018)

THU235 Usefulness Of Digital Droplet Polymerase Chain Reaction (ddPCR) For Molecular Diagnosis Of McCune-Albright Syndrome In DNA From Peripheral Blood Leukocytes
por: de Faria, Aline Guimarães, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_e4b02bk2r8f7n08gcaudff1g5u