Cargando…

IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity

Previous studies have shown reduced expression of Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) and its tumor-suppressive role in gastric cancer (GC). However, the precise role of SHIP2 in the migration and invasion of GC cells remains unclear. Here, an IQ motif containing the GTPase-ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Liang, Shao, Yuling, Ren, Lin, Liu, Xiansheng, Li, Yunyun, Xu, Jiegou, Ye, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139352/ https://www.ncbi.nlm.nih.gov/pubmed/32183047 http://dx.doi.org/10.3390/ijms21061968

Ejemplares similares

Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3
por: Jinawath, Natini, et al.
Publicado: (2020)

Decreased Sp1 Expression Mediates Downregulation of SHIP2 in Gastric Cancer Cells
por: Ye, Yan, et al.
Publicado: (2017)

The Antithetic Roles of IQGAP2 and IQGAP3 in Cancers
por: Song, Fei, et al.
Publicado: (2023)

IQGAP1 and IQGAP2 are Reciprocally Altered in Hepatocellular Carcinoma
por: White, Colin D, et al.
Publicado: (2010)

The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration
por: Kato, Katsuhiro, et al.
Publicado: (2012)

5′-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion
por: Rajadurai, Charles V., et al.
Publicado: (2016)

The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and Recruitment
por: Michael, Melina, et al.
Publicado: (2021)

Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers
por: Kumar, Dinesh, et al.
Publicado: (2017)

Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion
por: Mondal, Subhanjan, et al.
Publicado: (2012)

The Role of C2 Domains in Two Different Phosphatases: PTEN and SHIP2
por: John, Laura H., et al.
Publicado: (2023)

Endogenous IQGAP1 and IQGAP3 do not functionally interact with Ras
por: Morgan, Chase J., et al.
Publicado: (2019)

IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain
por: Atcheson, Erwan, et al.
Publicado: (2011)

IRTKS Promotes Insulin Signaling Transduction through Inhibiting SHIP2 Phosphatase Activity
por: Wu, Chongchao, et al.
Publicado: (2019)

RhoC Regulates the Proliferation of Gastric Cancer Cells through Interaction with IQGAP1
por: Wu, Yan, et al.
Publicado: (2012)

Structural basis for interdomain communication in SHIP2 providing high phosphatase activity
por: Le Coq, Johanne, et al.
Publicado: (2017)

β-Arrestin2 Regulates Lysophosphatidic Acid-Induced Human Breast Tumor Cell Migration and Invasion via Rap1 and IQGAP1
por: Alemayehu, Mistre, et al.
Publicado: (2013)

Correction: RhoC Regulates the Proliferation of Gastric Cancer Cells through Interaction with IQGAP1
por: Wu, Yan, et al.
Publicado: (2013)

TRIM56 acts through the IQGAP1-CDC42 signaling axis to promote glioma cell migration and invasion
por: Zhang, Qing, et al.
Publicado: (2023)

Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation
por: Brandt, Dominique T., et al.
Publicado: (2007)

Ras GTPase-Activating-Like Protein IQGAP1 (IQGAP1) Promotes Breast Cancer Proliferation and Invasion and Correlates with Poor Clinical Outcomes
por: Zeng, Fanye, et al.
Publicado: (2018)

The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics
por: Nakatsu, Fubito, et al.
Publicado: (2010)

Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation
por: Hoekstra, Elmer, et al.
Publicado: (2016)

Role of IQGAP1 in Carcinogenesis
por: Wei, Tao, et al.
Publicado: (2021)

Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma
por: Cui, Xiaobo, et al.
Publicado: (2017)

Downregulation of IQGAP2 Correlates with Prostate Cancer Recurrence and Metastasis()
por: Xie, Yanyun, et al.
Publicado: (2018)

Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro
por: Dong, Pei-Xin, et al.
Publicado: (2008)

The Overexpression of IQGAP1 and β-Catenin Is Associated with Tumor Progression in Hepatocellular Carcinoma In Vitro and In Vivo
por: Jin, Xuewen, et al.
Publicado: (2015)

Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases
por: Miletic, Ana V., et al.
Publicado: (2010)

Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion
por: Wang, Yan, et al.
Publicado: (2011)

IQGAP1 and IQGAP3 serve individually essential roles in normal epidermal homeostasis and tumor progression
por: Monteleon, Christine L., et al.
Publicado: (2015)

RNA Interference of IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Cell Proliferation and Invasion in Breast Carcinoma Cells
por: Hu, Gaowu, et al.
Publicado: (2016)

CDX2 Inhibits Invasion and Migration of Gastric Cancer Cells by Phosphatase and Tensin Homologue Deleted from Chromosome 10/Akt Signaling Pathway
por: Liu, Yong-Qiang, et al.
Publicado: (2015)

The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin
por: Dyson, Jennifer M., et al.
Publicado: (2001)

Evidence for SH2 Domain-Containing 5′-Inositol Phosphatase-2 (SHIP2) Contributing to a Lymphatic Dysfunction
por: Agollah, Germaine D., et al.
Publicado: (2014)

Transcript Profiling Identifies Iqgap2(−/−) Mouse as a Model for Advanced Human Hepatocellular Carcinoma
por: Gnatenko, Dmitri V., et al.
Publicado: (2013)

IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL
por: Tang, Tianjiao, et al.
Publicado: (2021)

An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells
por: Bartolini, Francesca, et al.
Publicado: (2016)

Targeting SHIP1 and SHIP2 in Cancer
por: Pedicone, Chiara, et al.
Publicado: (2021)

Lung Adenocarcinoma Cells Promote Self-Migration and Self-Invasion by Activating Neutrophils to Upregulate Notch3 Expression of Cancer Cells
por: Peng, Weidong, et al.
Publicado: (2022)

Lipid phosphatase SHIP‐1 regulates chondrocyte hypertrophy and skeletal development
por: So, Eui‐Young, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_4a1fkdarbc032fdevofv3k53o4