Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7

l-type amino acid transporter 1 (LAT1) is an amino acid transporter that is overexpressed in several types of cancer and, thus, it can be a potential target for chemotherapy. The objectives of this study were to (a) synthesize LAT1-targeted chlorambucil derivatives and (b) evaluate their LAT1-mediat...

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Detalles Bibliográficos
Autores principales: Pocasap, Piman, Weerapreeyakul, Natthida, Timonen, Juri, Järvinen, Juulia, Leppänen, Jukka, Kärkkäinen, Jussi, Rautio, Jarkko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139360/
https://www.ncbi.nlm.nih.gov/pubmed/32244913
http://dx.doi.org/10.3390/ijms21062132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139360/
https://www.ncbi.nlm.nih.gov/pubmed/32244913
http://dx.doi.org/10.3390/ijms21062132

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