Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer’s Disease Treatment

Human 17β-hydroxysteroid dehydrogenase type 10 is a multifunctional protein involved in many enzymatic and structural processes within mitochondria. This enzyme was suggested to be involved in several neurological diseases, e.g., mental retardation, Parkinson’s disease, or Alzheimer’s disease, in wh...

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Detalles Bibliográficos
Autores principales: Schmidt, Monika, Benek, Ondrej, Vinklarova, Lucie, Hrabinova, Martina, Zemanova, Lucie, Chribek, Matej, Kralova, Vendula, Hroch, Lukas, Dolezal, Rafael, Lycka, Antonin, Prchal, Lukas, Jun, Daniel, Aitken, Laura, Gunn-Moore, Frank, Kuca, Kamil, Musilek, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139388/
https://www.ncbi.nlm.nih.gov/pubmed/32192199
http://dx.doi.org/10.3390/ijms21062059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139388/
https://www.ncbi.nlm.nih.gov/pubmed/32192199
http://dx.doi.org/10.3390/ijms21062059

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