Karyotypic Flexibility of the Complex Cancer Genome and the Role of Polyploidization in Maintenance of Structural Integrity of Cancer Chromosomes

Ongoing chromosomal instability in neoplasia (CIN) generates intratumor genomic heterogeneity and limits the efficiency of oncotherapeutics. Neoplastic human cells utilizing the alternative lengthening of telomeres (ALT)-pathway, display extensive structural and numerical CIN. To unravel patterns of...

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Detalles Bibliográficos
Autores principales: Raftopoulou, Christina, Roumelioti, Fani-Marlen, Dragona, Eleni, Gimelli, Stefanie, Sloan-Béna, Frédérique, Gorgoulis, Vasilis, Antonarakis, Stylianos E., Gagos, Sarantis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139464/
https://www.ncbi.nlm.nih.gov/pubmed/32150835
http://dx.doi.org/10.3390/cancers12030591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139464/
https://www.ncbi.nlm.nih.gov/pubmed/32150835
http://dx.doi.org/10.3390/cancers12030591

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