Cargando…
Sexually Dimorphic Behavioral Profile in a Transgenic Model Enabling Targeted Recombination in Active Neurons in Response to Ketamine and (2R,6R)-Hydroxynorketamine Administration
Background: Rapid-acting antidepressants ketamine and (2R,6R)-hydroxynorketamine ((2R,6R)-HNK) have overcome some of the major limitations of classical antidepressants. However, little is known about sex-specific differences in the behavioral and molecular effects of ketamine and (2R,6R)-HNK in rode...
Autores principales: | Herzog, David P., Mellema, Ratnadevi M., Remmers, Floortje, Lutz, Beat, Müller, Marianne B., Treccani, Giulia |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139539/ https://www.ncbi.nlm.nih.gov/pubmed/32244978 http://dx.doi.org/10.3390/ijms21062142 |
Ejemplares similares
-
Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and
κ Opioid Receptors
por: Joseph, Thomas T., et al.
Publicado: (2021) -
(R,S)-ketamine and (2R,6R)-hydroxynorketamine differentially affect memory as a function of dosing frequency
por: Riggs, Lace M., et al.
Publicado: (2021) -
Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine
por: Shirayama, Yukihiko, et al.
Publicado: (2017) -
Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK)
por: Herzog, David P., et al.
Publicado: (2021) -
Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of
Ketamine’s Antidepressant Action
por: Aleksandrova, Lily R., et al.
Publicado: (2017)