Cargando…
Macrophage-Secreted Lipocalin-2 Promotes Regeneration of Injured Primary Murine Renal Tubular Epithelial Cells
Lipocalin-2 (Lcn-2) is rapidly upregulated in macrophages after renal tubular injury and acts as renoprotective and pro-regenerative agent. Lcn-2 possesses the ability to bind and transport iron with high affinity. Therefore, the present study focuses on the decisive role of the Lcn-2 iron-load for...
Autores principales: | Urbschat, Anja, Thiemens, Anne-Kathrin, Mertens, Christina, Rehwald, Claudia, Meier, Julia K., Baer, Patrick C., Jung, Michaela |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139578/ https://www.ncbi.nlm.nih.gov/pubmed/32188161 http://dx.doi.org/10.3390/ijms21062038 |
Ejemplares similares
-
The Fibrin Cleavage Product Bβ(15-42) Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury
por: Fischer, Dania, et al.
Publicado: (2018) -
The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma
por: Rehwald, Claudia, et al.
Publicado: (2019) -
Iron Handling in Tumor-Associated Macrophages—Is There a New Role for Lipocalin-2?
por: Jung, Michaela, et al.
Publicado: (2017) -
The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth
por: Schnetz, Matthias, et al.
Publicado: (2020) -
Iron-Bound Lipocalin-2 from Tumor-Associated Macrophages Drives Breast Cancer Progression Independent of Ferroportin
por: Mertens, Christina, et al.
Publicado: (2021)